Published in Innate Immunity, 2024
Koru Biotech’s research team has made a groundbreaking discovery in the fight against Gram-negative bacterial infections in dairy cows. In a world-first, scientists identified lipopolysaccharide/IgG (LPS/IgG) immune complexes in the milk of cows suffering from acute Escherichia coli-induced mastitis. These complexes are absent in healthy milk and show a strong correlation with LPS-driven inflammation, establishing them as a novel diagnostic and mechanistic biomarker for coliform mastitis.
Beyond Diagnostics: Two Breakthrough Innovations
Building on this discovery, Koru Biotech has pioneered two additional world-first advancements:
- Immune-Based Oral Vaccination for Calves
A novel approach using LPS/IgG complexes to stimulate protective intestinal immunity, offering early-life defense against Gram-negative pathogens. - Antibiotic-Free Therapeutic Strategy
A targeted method to disrupt the LPS-induced inflammatory cascade in the mammary gland—providing a new, sustainable pathway to treat infection and inflammation without antibiotics.
Transforming Dairy Health and Sustainability
Together, these innovations mark a paradigm shift in disease control, advancing:
- Animal welfare through early detection and non-antibiotic treatments
- Sustainable dairy production by reducing reliance on antibiotics
- Global applicability for farms combating coliform mastitis
About Innate Immunity
Innate Immunity is a leading peer-reviewed, open-access journal and the official publication of the International Endotoxin & Innate Immunity Society (IEIIS). It focuses on the chemistry, biology, and translational science of pathogen-associated molecular patterns, including Gram-negative endotoxins and their interaction with the innate immune system.